Do you wish you could have more time with your parents?
Not feel helpless at age 90?
See your grandchildren grow up?
It has become clear in the past decade that aging is not inevitable.
Please take 10 minutes to read everything.
If you agree with the message, send this site to others to spread the word.
If you disagree or have questions, let me know: @The_Matt_Brooks
Most death is due to aging
~150,000 people die each day across the globe.
About two-thirds - 100,000 per day - die from age-related causes such as cancer, Alzheimer's, heart disease, and others.
Chart comparing age-related deaths to non age-related deaths
Most suffering is due to aging
The majority of daily suffering is also due to aging.
The last years of a long life involve battling cancer, recovering from a heart attack or stroke, losing memories due to Alzheimer's, or other age-related suffering.
Nearly everyone across the globe will suffer in some way in their old age.
What is aging?
As you get older, the chance that you will die from certain diseases goes up dramatically.
Chart comparing age-related diseases.
Why? Well, like an old car, your body accumulates damage in a random fashion due to normal wear and tear.
The key to ending aging is categorizing these damages and figuring out ways to repair them. Like removing rust from a car, replacing the seals and gaskets, and changing the oil.
We now understand the damages that make up aging
With the rapid advancement of technology we now understand the 9 causes of aging:
  1. Our genes get damaged
  2. The caps on our DNA get shorter
  3. The way our genes act changes
  4. Proteins fold incorrectly
  5. Less available nutrients means less damage
  6. Our mitochondria starts to fail
  7. Some cells stop dividing but refuse to die
  8. Our reparative cells replicate less
  9. The way cells communicate starts creating damage
You can read the original paper or the simple explanations provided below.
1. Our genes get damaged
Genetic instability
As we age the damage to the genome from external sources like radiation or pollution, or internal sources such as free radicals builds up over time.
2. The caps on our DNA get shorter
Telomere attrition
Telomeres are sequences of DNA that protect the ends of chromosomes. Normal cell division and damage to the DNA shortens telomeres. When they get too short, cells sense it and permanently stop replicating.
3. The way our genes act changes
Epigenetic alterations
The epigenome is chemical compounds that attach to DNA and direct such actions as turning genes on or off, controlling the production of proteins in certain cells. As we age the epigenome changes and gene activity is compromised.
4. Proteins fold incorrectly
Loss of proteostasis
Proteostasis is the maintenance of all proteins in their original form and abundance. As we age proteins begin to fold incorrectly so they fail and clump together becoming toxic.
5. Less available nutrients means less damage
Deregulated nutrient sensing
When nutrients are scarce the body focuses on repairing itself. Tricking the body into thinking there are fewer nutrients available extends longevity.
6. Our mitochondria start to fail
Mitochondrial dysfunction
The “powerhouse of the cell” produces energy but also produces damaging free radicals that need to be kept in check. A decline in mitochondrial quality and activity is closely linked to aging and age-related diseases in general.
7. Some cells stop dividing but refuse to die
Cellular Senescence
Senescent cells are those that do not divide anymore but also do not die. We accumulate them as we age which causes damage.
8. Our reparative cells replicate less
Stem cell exhaustion
Healthy stem cells must replicate when required to regenerate and repair damage to our tissues and organs. Stems cells replicate less and replicate at the wrong time when we get older.
9. The way cells communicate starts creating damage
Altered intercellular communication
Communication among cells and tissues is important for maintaining health. As we age, the chemical messages across the body tends to become more inflammatory, inhibiting the immune system and causing damage.
Aging is not inevitable
There are many new promising categories of therapies that counteract aging.
Most likely there is not a single answer or “cure” but a wide range of therapies that can reduce or fix the different damages from the causes above.
Some of these therapies are:

Reasons we should end aging
Some people assume that because aging has always existed it somehow a good thing. Because we have never been able to stop aging we have chosen to accept it.
Below are some reasons we should end aging:

Myths & misconceptions about ending aging

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